Advanced colorectal cancer (CRC) survival rates are still low despite advances in cytotoxic
and targeted therapies. The development of new effective or alternative therapies is …

Scope Colorectal cancer is an important health problem across the world. Here, we
investigated the possible antiproliferative/proapoptotic effects of bromelain (from the …

Background Bromelain is a pineapple stem extract with a variety of therapeutic benefits
arising from interaction with a number of different biological processes. Several preclinical …

The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a
phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative …

Background Bromelain and N-acetylcysteine are two natural, sulfhydryl-containing
compounds with good safety profiles which have been investigated for their benefits and …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating
bacterial diarrhea and intestinal parasite infections. Although berberine has recently been …

Studies indicate that inhibiting a single signaling pathway or one single product of a gene is
insufficient for the prevention and treatment of cancer. This is due to the fact that …

Colorectal cancer is the second most common cause of cancer death in the world and about
half of the patients with colorectal cancer require adjuvant therapy after surgical resection …

Purpose: Extensive research over the past decade has revealed that the proinflammatory
microenvironment plays a critical role in the development of colorectal cancer. Whether …