The CB1 cannabinoid receptor, the main molecular target of endocannabinoids and
cannabis active components, is the most abundant G protein-coupled receptor in the …

Central nervous system responses to cannabis are primarily mediated by CB1 receptors,
which couple preferentially to Gi/o G proteins. Here, we used calcium photometry to monitor …

The endocannabinoid system is the target of the main psychoactive component of the plant
Cannabis sativa, the Δ9‐tetrahydrocannabinol (THC). This system is composed by the …

The cannabinoid signaling system is composed of cannabinoid (CB) receptors, their
endogenous ligands, the endocannabinoids, and the enzymes that produce and inactivate …

Cannabis use is associated with a wide range of pharmacological effects, some of which
have potential therapeutic benefit while others result in negative outcomes. Acute …

Acute Δ9-tetrahydrocannabinol (THC) injection increased ERK pathway (ERK, pCREB, and
c-fos) mostly in the caudate putamen and cerebellum. This effect underwent to homeostatic …

Cannabinoid CB1 receptors are the most abundant G-protein-coupled receptors in the brain.
Its presynaptic location suggests a role for cannabinoids in modulating the release of …

We have investigated whether a 1: 1 combination of botanical extracts enriched in either Δ9-
tetrahydrocannabinol (Δ9-THC) or cannabidiol (CBD), which are the main constituents of the …

After thousands of years of interest the last few decades have seen a huge increase in our
knowledge of the cannabinoids and their mode of action. Their potential as medical …

Cannabidiol (CBD), a major non-psychotomimetic constituent of Cannabis sativa, has
therapeutic potential for certain psychiatric and neurological disorders. Studies in laboratory …