The combination of luteolin and l-theanine improved Alzheimer disease–like symptoms by potentiating hippocampal insulin signaling and decreasing …

S Park, DS Kim, S Kang, HJ Kim - Nutrition research, 2018 - Elsevier
Luteolin and l-theanine have anti-inflammatory, antioxidant, and possible antidiabetic
activities, and they may synergistically protect against dementia. Here, we hypothesized that …

Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

JW Daily, S Kang, S Park - Biofactors, 2021 - Wiley Online Library
Luteolin is a widely distributed flavone herbs and vegetables. It has anti‐oxidant and anti‐
inflammatory activities and improves glucose metabolism by potentiating insulin sensitivity …

Luteolin attenuates diabetes-associated cognitive decline in rats

Y Liu, X Tian, L Gou, L Sun, X Ling, X Yin - Brain Research Bulletin, 2013 - Elsevier
Diabetes mellitus can cause dysfunction of the central nervous system called “diabetic
encephalopathy”. Although various oral drugs are used to treat diabetes, they do not prevent …

[HTML][HTML] Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice

S Jang, RN Dilger, RW Johnson - The Journal of nutrition, 2010 - Elsevier
A dysregulated overexpression of inflammatory mediators by microglia may facilitate
cognitive aging and neurodegeneration. Considerable evidence suggests the flavonoid …

Luteolin protects against high fat diet-induced cognitive deficits in obesity mice

Y Liu, X Fu, N Lan, S Li, J Zhang, S Wang, C Li… - Behavioural brain …, 2014 - Elsevier
The epidemic and experimental studies have confirmed that the obesity can lead to
neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the …

Agrimonia pilosa Ledeb., Cinnamomum cassia Blume, and Lonicera japonica Thunb. protect against cognitive dysfunction and energy and glucose dysregulation by reducing …

S Park, S Kang, DS Kim, BR Moon - Nutritional Neuroscience, 2017 - Taylor & Francis
Objectives: The water extracts of Cinnamomum cassia Blume bark (CCB; Lauraceae),
Lonicera japonica Thunb. flower (LJT; Caprifoliaceae), and Agrimonia pilosa Ledeb. leaves …

Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats

W Yang, J Ma, Z Liu, Y Lu, B Hu, H Yu - Neurological Sciences, 2014 - Springer
Recent evidence indicates that severe abnormalities in brain glucose/energy metabolism
and insulin signaling have been documented to take a pivotal role in early sporadic …

Alleviative effect of alpha-lipoic acid on cognitive impairment in high-fat diet and streptozotocin-induced type 2 diabetic rats

CY Ko, JH Xu, YM Lo, RS Tu, JSB Wu… - Frontiers in Aging …, 2021 - frontiersin.org
Background: The intricate relationship between type 2 diabetes mellitus (T2DM) and
Alzheimer's disease (AD) suggests that insulin is involved in modulating AD-related …

The ameliorating effects of luteolin on beta-amyloid-induced impairment of water maze performance and passive avoidance in rats

FS Tsai, HY Cheng, MT Hsieh, CR Wu… - The American Journal …, 2010 - World Scientific
The present study investigated the effects of luteolin on Aβ (1-40)-induced impairment of
Morris water maze (MWM) spatial performance, reference memory, and passive avoidance …

Luteolin ameliorates cognitive impairments by suppressing the expression of inflammatory cytokines and enhancing synapse-associated proteins GAP-43 and SYN …

J Gu, X Cheng, X Luo, X Yang, Y Pang, X Zhang… - Neurochemical …, 2018 - Springer
Luteolin, a flavonoid isolated from Cirsium japonicum, has antioxidant, anti-inflammatory
and neuroprotective activities. Our previous studies brought a prospect that luteolin …