Blood vessels form extensive networks that nurture all tissues in the body. Abnormal vessel
growth and function are hallmarks of cancer and ischemic and inflammatory diseases, and …

Critical limb ischemia (CLI) represents the most severe form of peripheral arterial disease.
Manifestations of CLI include rest pain, ischemic ulcers, and/or gangrene. The presence of …

Critical ischemia of the limbs or myocardium is frequently accompanied by diffuse distal
vascular disease making it unapproachable by conventional revascularization techniques …

Background Peripheral arterial disease (PAD), caused by narrowing of the arteries in the
limbs, is increasing in incidence and prevalence as our population is ageing and as …

Peripheral artery disease (PAD) is one of the major vascular complications in individuals
suffering from diabetes and in the elderly that can progress to critical limb ischemia (CLI) …

In multicellular organisms, angiogenesis, the formation of new blood vessels from pre-
existing ones, is an essential process for growth and development. Different mechanisms …

The vasculature is the first organ to arise during development. Blood vessels run through
virtually every organ in the body (except the avascular cornea and the cartilage), assuring …

The idea of promoting angiogenesis in ischemic tissues remains an undisputed therapeutic
approach for the treatment of myocardium and skeletal muscles that lack sufficient blood …

Peripheral arterial disease (PAD) has been historically neglected, which has resulted in a
lack of effective drugs in clinical practice. However, with the increasing prevalence of …

Peripheral artery disease (PAD) of the lower extremities is a common manifestation of
atherosclerosis that is increasing in global prevalence and in the associated public health …