For over a decade we have lived with the promise that therapeutic angiogenesis, defined as
the growth of new blood vessels in tissues damaged by poor blood perfusion, would provide …

Prognosis of peripheral artery disease (PAD), especially critical limb ischemia, is very poor
despite the development of endovascular therapy and bypass surgery. Many patients result …

The application of gene-and cell-based therapies to promote angiogenesis is a novel
concept to treat lower-limb critical limb ischemia (CLI) and may provide an unmet need for …

Introduction: Gene therapy has emerged as a novel therapy to promote angiogenesis in
patients with critical limb ischemia (CLI) caused by peripheral artery disease. Researchers …

Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

A number of pathological entities and surgical interventions could benefit from therapeutic
stimulation of new blood vessel formation. Although strategies designed for promoting …

Among the most exciting developments in vascular medicine is the targeting of specific
molecular regulators of blood vessel growth and development for therapeutic benefit …

The therapeutic potential of targeting tumor endothelium and vascular supply is now widely
recognized to treat different diseases. One such disease is cancer; where endothelial cells …

Background: Of the 200 million patients worldwide affected by peripheral arterial disease
(PAD), 4% will inevitably require major limb amputation. Previous systematic reviews …