Chagas disease is one of the most important endemic diseases in Latin America, caused by
Trypanosoma cruzi. The drugs used for the treatment of this disease, nifurtimox and …

Over the past decades, a number of 1, 4‐naphthoquinones have been isolated from natural
resources and several of naphthoquinone derivatives with diverse structural motif have been …

Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately
eight million individuals in the developing world; it is also classified as a neglected tropical …

The discovery and development of essential drugs for Chagas disease is a major concern
worldwide. New substituted 1, 4-naphthoquinones were synthesized and tested against the …

Derivatives of natural quinones with biological activities, such as lapachol, α-and β-
lapachones, have been synthesized and their trypanocidal activity evaluated in vitro in …

Four new naphthofuranquinones, obtained from 2-hydroxy-3-allyl-naphthoquinone (1) and
nor-lapachol (2), have their structures established by physical and X-ray analysis and their …

New oxirane derivatives were synthesized using six naphthoquinones as the starting
materials. Our biological results showed that these oxiranes acted as trypanocidal agents …

New naphthoquinone derivatives were synthesized and assayed against bloodstream
trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The …

Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1, 2, 3-triazolic para-
naphthoquinones, five nor-β-lapachone-based 1, 2, 3-triazoles, and several other …

The limited efficacy of benznidazole (Bz) indicated by failures of current Phase II clinical
trials emphasizes the urgent need to identify new drugs with improved safety and efficacy for …