A series of new 2-aminonaphthoquinones and related compounds were synthesized and
evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited …

The importance of American trypanosomiasis (Chagas' disease) in human pathology is
widely known. The prognosis of this disease is poor and the choice of effective medicines …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …

Chagas disease is caused by the hemoflagellate protozoa Trypanosoma cruzi and is one of
the most important neglected tropical diseases, especially in Latin American countries …

Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), is one of the most serious
parasitic diseases in Latin America. The currently available chemotherapy, based on …

As a continuation of our research and with the aim of obtaining new agents against Chagas
disease, an extremely neglected disease which threatens 100 million people, eighteen new …

Abstract Human African trypanosomiasis (HAT), Chagas disease and leishmaniasis, which
are caused by the trypanosomatids Trypanosoma brucei, Trypanosoma cruzi and …

Electronic, lipophilic and steric descriptors included in QSAR-2D and-3D are analyzed for a
set of ortho-and para-naphthoquinones that have proved to be powerful oxidative agents …

In this study, a series of 22 pre-synthesized 7-chloro-4-amino (oxy) quinoline derivatives
was assayed in vitro as potential antichagasic agents. A primary screening against …

Starting from α-and β-lapachones, in this work we compared the biological and theoretical
profile of several oxyran derivatives of lapachone as potential trypanocidal agents. Our …