Arylimidamides (AIAs) have been shown to have considerable biological activity against
intracellular pathogens, including Trypanosoma cruzi, which causes Chagas disease. In the …

In a screening of 65 derivatives of natural quinones using bloodstream trypomastigotes of
Trypanosoma cruzi, the 3 naphthoimidazoles derived from β-lapachone–N1, N2 and N3 …

Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Chagas disease, caused by the kinetoplastid protozoan parasite Trypanosoma cruzi,
remains a relevant cause of illness and premature death and it is estimated that 6 million to …

Objectives: Investigation of the mode of action of the naphthoimidazole N1, obtained from
the reaction of β-lapachone with benzaldehyde, which among 45 semi-synthetic derivatives …

Human African trypanosomiasis (HAT) is a deadly disease in need of new
chemotherapeutics that can cross into the central nervous system. We previously reported …

Chagas disease chemotherapy, currently based on only two drugs, nifurtimox and
benznidazole, is far from satisfactory and therefore the development of new antichagasic …

Background: Naphthoquinones are a class of aromatic compounds relevant for their
chemical characteristics, structural properties, and biological activity. These compounds are …

Chagas disease causes a problematic pathology that can lead to megacolon and heart
disease, and can even cause the death of the patient. Current therapies for this disease are …

Advocacy for better drugs and access to treatment has boosted the interest in drug discovery
and development for Chagas disease, a chronic infection caused by the genetically …