Understanding nuclear architecture is indispensable for understanding the cell-type-
dependent orchestration of active and silent genes and other nuclear functions, such as …

The organization of the genome in the nucleus of a eukaryotic cell is fairly complex and
dynamic. Various features of the nuclear architecture, including compartmentalization of …

The expression of genes is regulated at many levels. Perhaps the area in which least is
known is how nuclear organization influences gene expression. Studies of higher-order …

Genome-wide molecular studies have provided new insights into the organization of nuclear
chromatin by revealing the presence of chromatin domains of differing transcriptional …

Eukaryotic genomes are divided into chromosomes that occupy defined regions or territories
within the nucleus. These chromosome territories (CTs) are arranged based on the …

Chromosomes occupy distinct territories in the interphase cell nucleus. These chromosome
territories are non-randomly arranged within the nuclear space. We are only just uncovering …

This work reviews nuclear compartments, defined broadly to include distinct nuclear
structures, bodies, and chromosome domains. It first summarizes original cytological …

The genome must be highly compacted to fit within eukaryotic nuclei but must be accessible
to the transcriptional machinery to allow appropriate expression of genes in different cell …

We investigated the nuclear higher order compartmentalization of chromatin according to its
replication timing and the relations of this compartmentalization to chromosome structure …

The study of nuclear organization has radically changed the way we envision gene
regulation, imposing a paradigm shift from a seemingly featureless nucleus to a highly …