Alzheimer's disease (AD) is one of the most common forms of dementia and a significant
threat to the elderly populations, especially in the Western world. The rapid hydrolysis of the …

The inhibitory efficacy of two substituted coumarin derivatives on the activity of
neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer …

A large series of substituted coumarins linked through an appropriate spacer to 3‐hydroxy‐
N, N‐dimethylanilino or 3‐hydroxy‐N, N, N‐trialkylbenzaminium moieties were synthesized …

As a brain-destroying disorder, Alzheimer disease (AD) is the most common form of
dementia, which is widely seen in industrialized countries [1]. Besides its relation to the …

Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …

Alzheimer's disease (AD) leads to gradual memory loss including other compromised
cognitive abilities. Acetylcholinesterase (AChE), an important biochemical enzyme from the …

Acetylcholinesterase (AChE) plays an important role in Alzheimer's disease (AD). The
excessive activity of AChE causes various neuronal problems, particularly dementia and …

Acetylcholinesterase is an important enzyme, currently used as therapy for controlling the
effects of Alzheimer's disease that has been accepted as one of the major threats to the …

Acetylcholinesterase (AChE) is an important drug target for the treatment of Alzheimer's
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …

Alzheimer's disease (AD) is a brain disease characterized by gradual memory loss and
cognitive impairments. Acetylcholinesterase (AChE) inhibitors—such as donepezil …