Lung diseases such as fibrosis, asthma, cystic fibrosis, infection and cancer are life-
threatening conditions that slowly deteriorate quality of life and for which our diagnostic …

Recent advances in imaging offer exciting opportunities to develop and validate lung-
specific biomarkers as valuable adjuncts to diagnosis, tests of treatment efficacy, and/or …

Obstructive, interstitial, infectious and malignant lung diseases remain among the most
important health challenges and novel or improved therapeutic strategies are essential for …

Small animal models of lung fibrosis are essential for unraveling the molecular mechanisms
underlying human fibrotic lung diseases; additionally, they are useful for preclinical testing of …

Experimental in-vivo animal models are key tools to investigate the pathogenesis of lung
disease and to discover new therapeutics. Histopathological and biochemical investigations …

In vivo lung micro-computed tomography (micro-CT) is being increasingly embraced in
pulmonary research because it provides longitudinal information on dynamic disease …

Fundamentally important to the future of pulmonary medicine is a better description and
understanding of the human lung and its response to disease, injury, and treatment, which is …

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function
and may be characteristic of early pulmonary disease. While standard indices like …

Micro-computed tomography derived functional biomarkers used in lung disease research
can significantly complement end-stage histomorphometric measures while also allowing for …

The advent of micro-computed tomography (microCT) has provided significant advancement
in our ability to generate clinically relevant assessments of lung health and disease in small …