“You can observe a lot just by watching.”—Yogi Berra The androgen receptor (AR) is a
resilient foe. Since the landmark studies of Huggins et al1 demonstrated the sensitivity of …

The androgen/androgen receptor axis in prostate cancer : Current Opinion in Oncology The
androgen/androgen receptor axis in prostate cancer : Current Opinion in Oncology Log in or …

Functional androgen receptor (AR) signaling is necessary for the development of prostate
cancer. The therapeutic effect of androgen deprivation therapy for prostate cancer was …

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …

Androgens play a key role in the development and progression of prostate cancer, and
androgen deprivation therapy (ADT) is the first line treatment for advanced disease …

When prostate cancers progress following androgen depletion therapy, there are currently
few treatment options with only one, docetaxel, that has been shown to prolong life. Recent …

Prostate cancer is the most frequently diagnosed non‐skin cancer and the third leading
cause of cancer mortality in men. In the initial stages, prostate cancer is dependent on …

Prostate cancer is the most common cancer and the second leading cause of death from
cancer in males in most Western countries. Prostate cancer has an exquisite sensitivity to …

Although prostate cancer is heterogeneous in its etiology and progression, androgen
signaling through the androgen receptor (AR) appears to be involved in all aspects of the …

Advanced prostate tumors, which are androgen dependent, are often initially treated in the
clinic with hormone ablation therapy, either through surgical castration or administration of …