Abstract The p16/RB/E2F regulatory pathway, which controls transit through the G1
restriction point of the cell cycle, is one of the most frequent targets of genetic alterations in …

The E2F family of transcription factors consists of nine members with both distinct and
overlapping functions. These factors are situated downstream of growth factor signaling …

Ever since its discovery, the RB-1 gene and the corresponding protein, pRB, have been a
focal point of cancer research. The isolation of E2F transcription factors provided the key to …

The E2F transcription factor can regulate expression of numerous cellular genes controlling
proliferation, including proto-oncogenes and genes regulating cell cycle progression …

Deregulation of E2F transcriptional activity as a result of alterations in the p16INK4a-cyclin
D1-Rb pathway is a hallmark of human cancer. E2F is a family of related factors that controls …

Abstract E2F transcription factors (E2F1 to 6) are central players in the control of animal cell
proliferation as regulators of genes involved in cell cycle progression and in transformation …

Since its discovery, the E2F family of transcription factors has both fascinated and confused
researchers. What started as a simple model of positive regulation of genes required for …

The E2F family of transcription factors plays a pivotal role in the regulation of cell
proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either …

The p53 tumor suppressor protein is a transcription factor that exerts its effects on the cell
cycle via regulation of gene expression. Although the mechanism of p53-dependent …

The E2F family of transcription factors are essential for the regulation of genes required for
appropriate progression through the cell cycle. Five members of the E2F family have been …