An abnormality in adaptation to negative life events is considered as one of the main causes
of the development of depressive symptoms. According to the corticosteroid receptor …

Exposure to stress activates the hypothalamic–pituitary–adrenal axis and leads to increased
levels of glucocorticoid (GC) hormones. Prolonged elevation of GC levels causes neuronal …

Glucocorticoids are steroid hormones, secreted by the adrenal glands, that bind with high
affinity to brain mineralocorticoid receptors (MR) and lower affinity to glucocorticoid …

The diseases of civilization (arterial hypertension, atherosclerosis, sugar diabetes,
immunodeficiency, autoimmune pathology, bipolar disorders and depression) are of …

Here we review modern data on appearance and maintenance of depression at different
levels of the body. We discuss a role of impairments of emotional and motivation …

The hypothalamic-pituitary-adrenal (HPA) axis plays a primary role in the body response to
stresses. Activation of the HPA axis results in the production of corticosteroid hormones that …

Current research interest is increasingly directed towards the role of glucocorticoid actions
and inflammation. A failure in the stress system regulation appears to largely characterize …

Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the
glucocorticoid receptor (GR) have been linked to major depressive disorder. Given the …

Increasing evidence suggests that depression is characterised by impaired brain plasticity
that might originate from the interaction between genetic and environmental risk factors …

Stress-induced major depression and mood disorders are characterized by behavioural
abnormalities and psychiatric illness, leading to disability and immature mortality worldwide …