Although high high-density lipoprotein (HDL)-cholesterol levels are associated with
decreased cardiovascular risk in epidemiological studies, recent genetic and …

crease in HDL, whereas hepatic overexpression of scavenger receptor (SR)-BI with gene
transfer reduces atherosclerosis, despite a major reduction in HDL levels. 47, 48 …

The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol
and the risk of coronary heart disease, the protection of susceptible animals from …

Observational studies provide overwhelming evidence that a low high-density lipoprotein
(HDL)–cholesterol level increases the risk of coronary events, both in healthy subjects and …

Low levels of high-density lipoprotein (HDL) cholesterol constitute a risk factor for coronary
artery disease, and there is evidence that increasing HDL cholesterol levels reduces …

Clinical data show that a 1% increase in serum concentrations of high-density lipoprotein
cholesterol (HDL-C) can decrease cardiovascular risk by 2% to 3%. Therefore, mechanisms …

High-density lipoproteins (HDLs) are strongly related to risk of atherosclerotic cardiovascular
disease. Low levels of HDL cholesterol are a major cardiovascular risk factor, and …

Plasma HDL-cholesterol concentrations correlate negatively with the risk of atherosclerotic
cardiovascular disease (ASCVD). According to a widely cited model, HDL elicits its …

High-density lipoproteins (HDLs) are appropriately recognized for their many
atheroprotective functions, including reverse cholesterol transport, as well as antioxidant …

The risk of atherosclerosis is inversely related to circulating levels of high density lipoprotein
(HDL) cholesterol. Notably, in large-scale epidemiologic studies, this association is …