Aims There has been growing interest in the synthesis of new derivatives from isatin, found
in Isatis genus. Our objectives were to characterize the antinociceptive mechanism of action …

BACKGROUND: Isovaline, a nonproteinogenic α-amino acid rarely found in the biosphere,
is structurally similar to the inhibitory neurotransmitters glycine and γ-aminobutyric acid …

Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug production. Erdmann1 and Laurent2 …

Moxonidine is a mixed I1 imidazoline/α2-adrenergic receptor agonist structurally related to
clonidine. In the present studies, moxonidine, like clonidine, produced a dose-and time …

Inosine is the first metabolite of adenosine. It exerts an antinociceptive effect by activating
the adenosine A 1 and A 2A receptors. We have previously demonstrated that inosine …

The mixture of the two pentacyclic triterpenes α-amyrin and β-amyrin, isolated from the resin
of Protium kleinii and given by intraperitoneal (ip) or oral (po) routes, caused dose-related …

The influence of mianserin (5 or 3.6 mgkg− 1) on antinociceptive effect of morphine
(10mgkg− 1), metamizol (500mgkg− 1) and indomethacin (10 or 1.4 mgkg− 1) was …

Imidazolidine derivatives, or hydantoins, are synthetic compounds with different therapeutic
applications. Many imidazolidine derivatives have psychopharmacological properties, such …

Despite synergistic morbidity and mortality, concomitant consumption of alcohol and tobacco
is increasing, and their antinociceptive effect has been linked with co‐abuse. Present study …

The present study examined the antinociceptive effects of agmatine in chemical behavioural
models of pain. Agmatine (1–30 mg/kg), given by ip route, 30 min earlier, produced dose …