The discovery of the RANKL/RANK/OPG system in the mid 1990s for the regulation of bone
resorption has led to major advances in our understanding of how bone modeling and …

Understanding of osteoclast formation and activation has advanced considerably since the
discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem …

The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/
osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies …

Bone‐related diseases, such as osteoporosis and rheumatoid arthritis, affect hundreds of
millions of people worldwide and pose a tremendous burden to health care. By deepening …

1997 saw the identification of a novel set of proteins within the tumor necrosis factor
(TNF)/TNF receptor families that are required for the control of bone remodeling. Therefore …

The receptor activator of nuclear factor‑κB ligand (RANKL)/RANK/osteoprotegerin (OPG)
system was identified in the late 1990s, ending the search for the specific factors expressed …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

Osteoclasts are highly specialized cells capable of degrading mineralized tissue and form at
different regions of bone to meet different physiological needs, such as mobilization of …

Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …

Bone remodeling requires a precise balance between resorption and formation. It is a
complex process that involves numerous factors: hormones, growth factors, vitamins, and …