Cyclic AMP affects oocyte maturation and embryo development in prepubertal and adult cattle

SM Bernal-Ulloa, J Heinzmann, D Herrmann… - PloS one, 2016 - journals.plos.org
High cAMP levels during in vitro maturation (IVM) have been related to improved blastocyst
yields. Here, we employed the cAMP/cGMP modulators, forskolin, IBMX, and cilostamide …

Effects of different oocyte retrieval and in vitro maturation systems on bovine embryo development and quality

SM Bernal, J Heinzmann, D Herrmann, B Timmermann… - Zygote, 2015 - cambridge.org
Cyclic adenosine monophosphate (cAMP) modulators have been used to avoid
spontaneous oocyte maturation and concomitantly improve oocyte developmental …

Exogenous dibutyryl cAMP affects meiotic maturation via protein kinase A activation; it stimulates further embryonic development including blastocyst quality in pigs

JS Kim, YS Cho, BS Song, G Wee, JS Park, YK Choo… - Theriogenology, 2008 - Elsevier
High concentrations of cyclic AMP in germinal vesicle oocytes generally inhibit GVBD. Thus,
maintaining the GV stage in growing oocytes is essential for the developmental competence …

Role of cAMP modulator supplementations during oocyte in vitro maturation in domestic animals

GR Leal, CAS Monteiro, JMG Souza-Fabjan… - Animal reproduction …, 2018 - Elsevier
Cyclic adenosine monophosphate (cAMP) is an important molecule in signal transduction
within the cell, functioning as a second cell messenger of gonadotrophin stimulation. The …

Regulation of sheep oocyte maturation using cAMP modulators

RD Rose, RB Gilchrist, JM Kelly, JG Thompson… - Theriogenology, 2013 - Elsevier
Physical removal of mammalian cumulus-oocyte complexes (COCs) from ovarian follicles
results in spontaneous resumption of meiosis, largely because of a decrease in cAMP …

Transcriptomic analysis of cyclic AMP response in bovine cumulus cells

DR Khan, C Guillemette, MA Sirard… - Physiological …, 2015 - journals.physiology.org
Acquisition of oocyte developmental competence needs to be understood to improve clinical
outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic …

Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle

S Sugimura, T Yamanouchi, MG Palmerini… - … of Reproduction and …, 2018 - jstage.jst.go.jp
The administration of follicle-stimulating hormone (FSH) prior to oocyte retrieval improves
oocyte developmental competence. During bovine embryo production in vitro, however …

Meiotic arrest maintained by cAMP during the initiation of maturation enhances meiotic potential and developmental competence and reduces polyspermy of IVM/IVF …

T Somfai, K Kikuchi, A Onishi, M Iwamoto, D Fuchimoto… - Zygote, 2003 - cambridge.org
We investigated effects of invasive adenylate cyclase (iAC), 3-isobutyl-1-methylxanthine
(IBMX) and dibutyryl cyclic AMP (dbcAMP) on porcine oocyte in vitro maturation (IVM), in …

Effect of dibutyryl cAMP on the cAMP content, meiotic progression, and developmental potential of in vitro matured pre‐pubertal and adult pig oocytes

MA Bagg, MB Nottle, CG Grupen… - Molecular …, 2006 - Wiley Online Library
Pre‐pubertal pig oocytes display reduced developmental competence compared with adult
oocytes following in vitro maturation (IVM). Exposure to dibutyryl cyclic adenosine …

Increasing the cAMP concentration during in vitro maturation of pig oocytes improves cumulus maturation and subsequent fertilization in vitro

R Appeltant, J Beek, L Vandenberghe, D Maes… - Theriogenology, 2015 - Elsevier
Porcine IVF faces various problems such as incomplete cytoplasmic maturation of the oocyte
and polyspermy. Previous studies proved the importance of cAMP in regulating nuclear and …