In a model of peripherally induced inflammatory pain in rats, selective inhibitors of
cyclooxygenase (COX)-2 raised nociceptive thresholds above basal values, an effect …

Celecoxib is a selective inhibitor of cyclooxygenase-2 (COX-2) and blocks prostaglandin
(PG) biosynthesis associated with inflammatory conditions. In a model of peripherally …

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits
cyclooxygenase-2 (COX-2). Like most NSAIDs, celecoxib exhibits analgesic effects in …

It is well‐established that inhibitors of cyclo‐oxygenase (COX) and hence of prostaglandin
(PG) biosynthesis reverse inflammatory hyperalgesia and oedema in both human and …

Background Celecoxib exerted analgesic effects (hypoalgesia) reversed by opioid receptor
antagonists in a model of inflammatory pain. To analyze this celecoxib-induced hypoalgesia …

Non-steroidal antiinflammatory drugs (NSAIDs) are known to induce analgesia mainly via
inhibition of cyclooxygenase (COX). Although the inhibition of COX in the periphery is …

Mechanical hyperalgesia induced in rat paws by carrageenan (250μg) was modified by pre-
treatment with three selective inhibitors of cyclo-oxygenase-2 (COX-2); celecoxib, rofecoxib …

The effects of selective cyclooxygenase-2 (COX-2) inhibitors in biological functions are
frequently investigated in animal models. However, there is little data on their analgesic …

The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the
formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) …

Administration of formalin in rat paws results in stimulation of nociceptive pathways, which
leads to an increase in the excitability of neurons present in dorsal horn. This increased …