Background: Depressive disorders are commonly comorbid with alcoholism, particularly in
treatmentseeking samples. If antidepressant treatment were safe and improved the …

Of 60 depressed alcoholics who completed an open trial of imipramine, 27 (45%) responded
with improvement in both mood and drinking behavior, and eight (13%) responded after …

Objective.—To assess the use of desipramine for secondary depression in primary alcohol
dependence and its effect on abstinence. Design.—Randomized, double-blind, placebo …

Background The literature is inconclusive on the role of antidepressant medications in
treating drug dependence. Studies have either not focused on depressed patients or have …

The use of antidepressant pharmacotherapy to treat patients with co-occurring depression
and alcohol dependence is controversial. There is a stigma attached to giving medications …

ContextDepression and substance abuse are common and costly disorders that frequently
co-occur, but controversy about effective treatment for patients with both disorders persists …

Objective: The aim of the study was to evaluate possible new treatments for major
depressive disorder in patients with comorbid alcohol dependence in a municipal alcohol …

This paper reviews recent literature on the prevalence of alcohol dependence and affective
disorders (major depression, dysthymia), the comorbidity of these conditions and the effects …

Depression has been related to relapsed drinking in alcoholics striving to maintain sobriety.
Treatment with tricyclic antidepressants might reverse or prevent depressive symptoms …

The relationships of depression with alcohol and drug use and impairment were examined.
Additional analyses were conducted to examine moderators of these associations. Empirical …