The pathogenesis of Alzheimer's disease (AD) is well documented to involve mitochondrial
dysfunction which causes subsequent oxidative stress and energy metabolic failure in …

Methylene blue (MB) phase II clinical trials reported improvements in cognitive functions of
Alzheimer's disease (AD) patients. Regarding MB mechanism of action, its antioxidant and …

Methylene blue (MB) can be used as a multidirectional neuroprotector to stop the
development of multiple cascades of neuron damage during neurodegenerative processes …

Multiple sclerosis (MS) is a neurodegenerative disease. Although multiple factors are
involved in the pathogenesis of MS, there are several lines of evidence that oxidative stress …

By restoring mitochondrial function, methylene blue (MB) is an effective neuroprotectant in
many neurological disorders (eg, Parkinson's and Alzheimer's diseases). MB has also been …

Age-related brain dysfunctions are associated with mitochondria malfunctions and
increased risk of developing neurodegenerative diseases (ND). Recently, a mitochondria …

Rationale Mitochondrial dysfunction has been well documented in age related disorders like
Alzheimer's disease. Alterations in mitochondrial membrane potential lead to neuronal …

Transient global cerebral ischemia (GCI) causes delayed neuronal cell death in the
vulnerable hippocampus CA1 subfield, as well as behavioral deficits. Ischemia reperfusion …

Methylene blue (MB) belongs to the phenothiazinium family. It has been used to treat a
variety of human conditions and has beneficial effects on the central nervous system in …

Traumatic brain injury (TBI) leads to permanent neurological impairment, and methylene
blue (MB) exerts central nervous system neuroprotective effects. However, only one …