Reproductive diseases have become a growing worldwide problem and male factor plays
an important role in the reproductive diagnosis, prognosis and design of assisted …

Sperm DNA contributes half the offspring's genomic material and abnormal DNA can lead to
derangements in the reproductive process. Normal sperm genetic material is required for …

Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of
assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo …

Male factor is responsible for up to 50% of infertility cases in the world. Semen analysis is
considered the cornerstone of laboratory evaluation of male infertility, but it has its own …

While the semen analysis has traditionally been relied upon to differentiate fertile and
infertile men, its utility has been questioned in the current era of assisted reproductive …

Among the different DNA anomalies that can be present in the male gamete, DNA
fragmentation is the most frequent, particularly in infertile subjects. There is now consistent …

Evidence suggests that damage to human sperm DNA might adversely affect reproductive
outcomes and that the spermatozoa of infertile men possess substantially more sperm DNA …

The advent of assisted reproductive technologies, particularly intracytoplasmic sperm
injection (ICSI), has revolutionized the treatment of male‐factor infertility. However, there are …

There now exists clinical evidence to show that sperm DNA damage is detrimental to
reproductive outcomes. Tests for DNA damage may provide better prognostic information …

DNA fragmentation, or the accumulation of single-and double-strand DNA breaks, is a
common property of sperm, and an increase in the level of sperm DNA fragmentation is …