A new liquid chromatography/mass spectrometry method for 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanol (NNAL) in urine

SH Bhat, SL Gelhaus, C Mesaros… - Rapid …, 2011 - Wiley Online Library
(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) is a carcinogenic nitrosamine
produced upon curing tobacco. It is present in tobacco smoke and undergoes metabolism to …

Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid …

P Jacob III, C Havel, DH Lee, L Yu, MD Eisner… - Analytical …, 2008 - ACS Publications
Exposure to secondhand tobacco smoke (SHS) has been linked to increased risk for a
number of diseases, including lung cancer. The tobacco-specific nitrosamine 4 …

Development of a rapid method for the simultaneous separation and determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its N-and O-glucuronides in …

L Yao, S Zheng, Y Guan, J Yang, B Liu, W Wang… - Analytica Chimica …, 2013 - Elsevier
Determination of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanol (NNAL) and its N-and O-glucuronides (NNAL-N-Gluc and NNAL-O-Gluc) …

Urine concentrations of a tobacco-specific nitrosamine carcinogen in the US population from secondhand smoke exposure

JT Bernert, JL Pirkle, Y Xia, RB Jain, DL Ashley… - … , biomarkers & prevention, 2010 - AACR
Background: The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and its reduction product in the body, 4-(methylnitrosamino)-1-(3-pyridyl)-1 …

Metabolism of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone to its biomarker total NNAL in smokeless tobacco users

SS Hecht, SG Carmella, I Stepanov, J Jensen… - … Biomarkers & Prevention, 2008 - AACR
Abstract The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) is one of the most abundant carcinogens in smokeless tobacco products. NNK uptake …

Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine

SG Carmella, S Han, A Fristad, Y Yang… - … Biomarkers & Prevention, 2003 - AACR
A new method was developed for the analysis of metabolites of the tobacco-specific lung
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human urine. The …

Rapid quantitation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in rat urine using …

E Sepehr, KA Woodling, MS Bryant - Journal of Liquid …, 2018 - Taylor & Francis
ABSTRACT The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) is a component of tobacco smoke and is rapidly metabolized to 4 …

Analysis of N- and O-Glucuronides of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in Human Urine

SG Carmella, K Le, P Upadhyaya… - Chemical research in …, 2002 - ACS Publications
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific lung carcinogen
which may play an important role as a cause of lung cancer in smokers. NNK is extensively …

Characterization of N-glucuronidation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human liver: importance of UDP …

D Wiener, DR Doerge, JL Fang, P Upadhyaya… - Drug metabolism and …, 2004 - ASPET
The nicotine-derived tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK), is one of the most potent and abundant procarcinogens found in tobacco …

Tobacco-Specific Nitrosamines and Their Pyridine-N-glucuronides in the Urine of Smokers and Smokeless Tobacco Users

I Stepanov, SS Hecht - Cancer Epidemiology Biomarkers & Prevention, 2005 - AACR
Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in
people who use tobacco products. Whereas the uptake of one tobacco-specific nitrosamine …