Glioblastoma multiforme (GBM) frequently involves amplification and alteration of the
epidermal growth factor receptor (EGFR) gene, resulting in overexpression of varied …

Purpose: The epidermal growth factor receptor (EGFR) is overexpressed in∼ 50% to 60% of
glioblastoma multiforme tumors, and the most common EGFR mutant, EGFRvIII, is …

Amplification of the epidermal growth factor receptor (EGFR) gene occurs in approximately
40% of cases of glioblastoma multiforme (GBM) and is considered a possible marker of poor …

Purpose There is a great controversy regarding the prognostic significance of epidermal
growth factor receptor (EGFR) in glioma patients. The current meta-analysis was conducted …

The epidermal growth factor receptor variant III (EGFRvIII) is associated with increased
proliferation of glioma cells. However, the impact of EGFRvIII on survival of patients with …

Background The epidermal growth factor receptor (EGFR) is over expressed in
approximately 50–60% of glioblastoma (GBM) tumors, and the most common EGFR mutant …

Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about
half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR …

Purpose The clinical significance of epidermal growth factor receptor variant III (EGFRvIII)
expression in glioblastoma multiforme (GBM) and its relationship with other key molecular …

Background The efficacy of novel targeted therapies is often tested at the time of tumor
recurrence. However, for glioblastoma (GBM) patients, surgical resections at recurrence are …

Background Protein tyrosine kinases are important regulators of cellular homeostasis with
tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the …