The comet assay as a tool for human biomonitoring studies: the ComNet project
The comet assay is widely used in human biomonitoring to measure DNA damage as a
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies …
marker of exposure to genotoxic agents or to investigate genoprotective effects. Studies …
The comet assay: a sensitive genotoxicity test for the detection of DNA damage and repair
G Speit, A Hartmann - DNA Repair Protocols: Mammalian Systems, 2006 - Springer
The comet assay (single-cell gel electrophoresis) is a simple and sensitive method for
studying DNA damage and repair. In this microgel electrophoresis technique, a small …
studying DNA damage and repair. In this microgel electrophoresis technique, a small …
Measuring DNA modifications with the comet assay: a compendium of protocols
A Collins, P Møller, G Gajski, S Vodenková… - Nature protocols, 2023 - nature.com
The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …
[HTML][HTML] The hCOMET project: International database comparison of results with the comet assay in human biomonitoring. Baseline frequency of DNA damage and …
The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular
methods for assessing DNA damage in human population. One of the open issues …
methods for assessing DNA damage in human population. One of the open issues …
Assessment and reduction of comet assay variation in relation to DNA damage: studies from the European Comet Assay Validation Group
P Møller, L Möller, RWL Godschalk, GDD Jones - Mutagenesis, 2010 - academic.oup.com
The alkaline single cell gel electrophoresis (comet) assay has become a widely used
method for the detection of DNA damage and repair in cells and tissues. Still, it has been …
method for the detection of DNA damage and repair in cells and tissues. Still, it has been …
An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human …
C Ersson, P Møller, L Forchhammer, S Loft… - …, 2013 - academic.oup.com
The alkaline comet assay is an established, sensitive method extensively used in
biomonitoring studies. This method can be modified to measure a range of different types of …
biomonitoring studies. This method can be modified to measure a range of different types of …
Does the duration of lysis affect the sensitivity of the in vitro alkaline comet assay?
JM Enciso, O Sánchez, A López de Cerain… - Mutagenesis, 2015 - academic.oup.com
The alkaline comet assay is now the method of choice for measuring different kinds of DNA
damage in cells. Several attempts have been made to identify and evaluate the critical …
damage in cells. Several attempts have been made to identify and evaluate the critical …
Measurement of DNA damage with the comet assay in high-prevalence diseases: current status and future directions
P Møller, H Stopper, AR Collins - Mutagenesis, 2020 - academic.oup.com
The comet assay is widely used in studies on genotoxicity testing, human biomonitoring and
clinical studies. The simple version of the assay detects a mixture of DNA strand breaks and …
clinical studies. The simple version of the assay detects a mixture of DNA strand breaks and …
[HTML][HTML] Measurement of oxidatively damaged DNA in mammalian cells using the comet assay: reflections on validity, reliability and variability
P Møller - Mutation Research/Genetic Toxicology and …, 2022 - Elsevier
The comet assay is a simple technique for measurements of low levels of DNA damage and
repair in single cells. However, there is variation in background levels of DNA damage in …
repair in single cells. However, there is variation in background levels of DNA damage in …
Comet assay: a versatile but complex tool in genotoxicity testing
E Cordelli, M Bignami, F Pacchierotti - Toxicology Research, 2021 - academic.oup.com
The comet assay is a versatile method for measuring DNA strand breaks in individual cells. It
can also be applied to cells isolated from treated animals. In this review, we highlight …
can also be applied to cells isolated from treated animals. In this review, we highlight …