Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

Y Chao, LR Marks, MM Pettigrew… - Frontiers in cellular and …, 2015 - frontiersin.org
Streptococcus pneumoniae (the pneumococcus) is a common colonizer of the human
nasopharynx. Despite a low rate of invasive disease, the high prevalence of colonization …

Pneumococcal Interactions with Epithelial Cells Are Crucial for Optimal Biofilm Formation and Colonization In Vitro and In Vivo

LR Marks, GI Parameswaran… - Infection and …, 2012 - Am Soc Microbiol
The human nasopharynx is the main reservoir for Streptococcus pneumoniae (the
pneumococcus) and the source for both horizontal spread and transition to infection. Some …

Interkingdom signaling induces Streptococcus pneumoniae biofilm dispersion and transition from asymptomatic colonization to disease

LR Marks, BA Davidson, PR Knight, AP Hakansson - MBio, 2013 - Am Soc Microbiol
Streptococcus pneumoniae is a common human nasopharyngeal commensal colonizing
10% to 40% of healthy individuals, depending on age. Despite a low invasive disease rate …

Streptococcus pneumoniae in Biofilms Are Unable to Cause Invasive Disease Due to Altered Virulence Determinant Production

CJ Sanchez, N Kumar, A Lizcano, P Shivshankar… - PloS one, 2011 - journals.plos.org
It is unclear whether Streptococcus pneumoniae in biofilms are virulent and contribute to
development of invasive pneumococcal disease (IPD). Using electron microscopy we …

Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization

RP Gilley, CJ Orihuela - Frontiers in cellular and infection …, 2014 - frontiersin.org
Streptococcus pneumoniae (the pneumococcus) is an opportunistic pathogen that colonizes
the human nasopharynx asymptomatically. Invasive pneumococcal disease develops …

Streptococcus pneumoniae biofilm formation is strain dependent, multifactorial, and associated with reduced invasiveness and immunoreactivity during colonization

K Blanchette-Cain, CA Hinojosa, R Akula Suresh Babu… - MBio, 2013 - Am Soc Microbiol
Biofilms are thought to play an important role during colonization of the nasopharynx by
Streptococcus pneumoniae, yet how they form in vivo and the determinants responsible …

Early biofilm formation on microtiter plates is not correlated with the invasive disease potential of Streptococcus pneumoniae

A Lizcano, T Chin, K Sauer, EI Tuomanen… - Microbial …, 2010 - Elsevier
Biofilm formation has been suggested to play an important role during Streptococcus
pneumoniae nasopharyngeal colonization and may facilitate progression to pneumonia. To …

Pneumococcal biofilms

M Moscoso, E García, R López - 2009 - digital.csic.es
Over 60% of bacterial infections (and up to 80% of chronic infections) are currently
considered to involve microbial growth in biofilms. This peculiar form of life poses an array of …

Biofilm formation avoids complement immunity and phagocytosis of Streptococcus pneumoniae

M Domenech, E Ramos-Sevillano, E García… - Infection and …, 2013 - Am Soc Microbiol
Streptococcus pneumoniae is a frequent member of the microbiota of the human
nasopharynx. Colonization of the nasopharyngeal tract is a first and necessary step in the …

High levels of genetic recombination during nasopharyngeal carriage and biofilm formation in Streptococcus pneumoniae

LR Marks, RM Reddinger, AP Hakansson - MBio, 2012 - Am Soc Microbiol
Transformation of genetic material between bacteria was first observed in the 1920s using
Streptococcus pneumoniae as a model organism. Since then, the mechanism of …