The mitochondrial respiratory apparatus is the product of both nuclear and mitochondrial
genes. The protein coding capacity of mtDNA is restricted to the expression of 13 respiratory …

The majority of gene products required for mitochondrial respiratory function are encoded in
the nuclear genome. These include most of the respiratory subunits and all of the proteins …

Expression of the respiratory apparatus depends on both nuclear and mitochondrial genes.
Although these genes are sequestered in distinct cellular organelles, their transcription …

The biogenesis of mitochondria requires the expression of a large number of genes, most of
which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13 …

In vertebrates, mitochondrial DNA (mtDNA) transcription is initiated bidirectionally from
closely spaced promoters, HSP and LSP, within the D-loop regulatory region. Early studies …

The biogenesis and function of mitochondria rely upon the regulated expression of nuclear
genes. Recent evidence points to both transcriptional activators and coactivators as …

Mitochondria contain their own genetic system and undergo a unique mode of cytoplasmic
inheritance. Each organelle has multiple copies of a covalently closed circular DNA genome …

Mitochondrial transcription factor A (mtTFA), the product of a nuclear gene, stimulates
transcription from the two divergent mitochondrial promoters and is likely the principal …

The assembly of the respiratory apparatus requires the coordinate expression of a large
number of genes from both nuclear and mitochondrial genetic systems. In vertebrate …

Nucleus-encoded regulatory factors are major contributors to mitochondrial biogenesis and
function. Several act within the organelle to regulate mitochondrial transcription and …