Methylisoguanosine, a marine natural product with potent muscle-relaxant and
cardiovascular actions in vivo, interacts directly with adenosine receptors in guinea-pig brain …

Adenosine analogues inhibit rat cerebral cortical adenylate cyclase by a receptor-mediated
GTP-dependent process. N 6-Phenylisopropyladenosine and other analogues of adenosine …

When tested under conditions reducing the endogenous production of adenosine (presence
of adenosine deaminase (ADA) 1.6 IU/ml; and deoxyadenosine triphosphate (d-ATP)), and …

Methylisoguanosine is a marine natural product with skeletal muscle relaxant, hypothermic
and cardiovascular effects following oral administration in mice and rats. The cardiovascular …

Two adenosine receptor sites have been detected in striatal homogenates. One triggered
the stimulation and the other the inhibition of the adenylate cyclase. They clearly had …

There is a good deal of evidence suggesting that adenosine and its phosphorylated
derivatives (adenosine mono-, di-and triphosphate) might act in the brain like a …

Membranes from rat cerebral cortex and striatum contain a relatively large number of high-
affinity binding sites for [3 H] 2′, 5′-didepxyadenosine,[3 H] adenine arabinoside, and [3 …

(N-Ethylcarboxamido) adenosine (NECA) and N 6-[(R)-(phenylisopropyl)] adenosine (PIA)
were incubated in an adenylate cyclase assay with a particulate fraction of caudate-putamen …

The effects of adenosine receptor agonists on cyclic nucleotides accumulation were
investigated in adult guinea-pig cerebellar slices by use of radioactive precursors. 2 …

1. Adenosine by interaction with discrete extracellular recognition sites can modulate cyclic
AMP formation and cell firing in the mammalian CNS. 2. 2. The effects of adenosine on cyclic …