A critical limitation of bioorthogonal click chemistry for in vivo applications has been its low
reaction efficiency due to the pharmacokinetic barriers, such as blood distribution …

Bioorthogonal click chemistry, first introduced in the early 2000s, has become one of the
most widely used approaches for designing advanced biomaterials for applications in tissue …

The rapid advancement of bio-orthogonal click chemistry in the past decade has enabled
the study and precise manipulation of biological processes within living organisms. The …

Over the last two decades, click chemistry and bioorthogonal chemistry have revolutionized
the field of biomedical engineering. Extensive investigations have been conducted and …

The fields of precision imaging and drug delivery have revealed a number of tools to
improve target specificity and increase efficacy in diagnosing and treating disease …

The recent discovery of bioorthogonal click chemistry has created a new field in chemical
biology in which biomolecules that are not directly encoded in the genome can be monitored …

Over the past two decades, bioorthogonal chemistry has profoundly impacted various
chemistry-related fields, including chemical biology and drug delivery. This transformative …

Bioorthogonal click reactions yielding stable and irreversible adducts are in high demand for
in vivo applications, including in biomolecular labeling, diagnostic imaging, and drug …

Click chemistry has become a commonly used synthetic method due to the simplicity,
efficiency, and high selectivity of this class of chemical reactions. Since their initial discovery …

Amine-targeting reactions that work under biocompatible conditions or in water are green
processes that are extremely useful for the synthesis of functional materials and …