Background CD31 is a key transmembrane neutrophil immunoregulatory receptor.
Mesenteric ischemia/reperfusion-induced neutrophil activation leads to a massive cleavage …

Complement activation is critical in the development of local mucosal damage and
inflammation as well as of remote organ injury after mesenteric ischemia/reperfusion. To …

Gut ischemia/reperfusion (I/R) provokes lung injury via a mechanism that involves
neutrophils [polymorphonuclear neutrophils (PMNs)]. CD11b/CD18 (alphamBsub 2) is the …

Background and Aims: Complement activation plays an important role in the local
pathogenesis of ischemia/reperfusion (I/R) injury. We investigated the action of anti-C5 …

Background To investigate the therapeutic effect of monoclonal antibody (mAb)–induced
CD16 (FcγRIII) inhibition in a murine model of high-grade (severe) sepsis. Materials and …

Background Ischemia-reperfusion injury (I/R) is an inflammatory response to hypoxia that is
dependent on antibodies. We have previously shown that the N2 peptide blocks binding of …

Neutrophils play an important role in ischemia-reperfusion (I/R)-induced vascular injury in
the small intestine. Monoclonal antibodies against the leukocyte adhesion glycoprotein …

Objectives: Sepsis is associated with a systemic inflammatory reaction, which can result in a
life-endangering organ dysfunction. Pro-inflammatory responses during sepsis are …

Antibodies to the neutrophil CD18 integrin have been shown to ameliorate the local effects
of intestinal ischemia and reperfusion (I/R). In addition to local mucosal injury, intestinal I/R …

C5 is critical in the development of local mucosal damage and inflammation as well as in the
development of remote organ injury after mesenteric ischemia/reperfusion (IR). To define the …