Intestinal redox biology and oxidative stress
ML Circu, TY Aw - Seminars in cell & developmental biology, 2012 - Elsevier
The intestinal epithelium sits at the interface between an organism and its luminal
environment, and as such is prone to oxidative damage induced by luminal oxidants …
environment, and as such is prone to oxidative damage induced by luminal oxidants …
Redox biology of the intestine
ML Circu, TY Aw - Free radical research, 2011 - Taylor & Francis
The intestinal tract, known for its capability for self-renew, represents the first barrier of
defence between the organism and its luminal environment. The thiol/disulfide redox …
defence between the organism and its luminal environment. The thiol/disulfide redox …
Cellular redox: a modulator of intestinal epithelial cell proliferation
TY Aw - Physiology, 2003 - journals.physiology.org
Mucosal proliferation, together with differentiation and apoptosis, are a continuous
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
homeostatic process in the intestinal epithelium. The glutathione/glutathione disulfide redox …
Redox signaling in the gastrointestinal tract
S Pérez, R Taléns-Visconti, S Rius-Pérez… - Free Radical Biology …, 2017 - Elsevier
Redox signaling regulates physiological self-renewal, proliferation, migration and
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch …
[HTML][HTML] Control and dysregulation of redox signalling in the gastrointestinal tract
EL Campbell, SP Colgan - Nature Reviews Gastroenterology & …, 2019 - nature.com
Redox signalling in the gastrointestinal mucosa is held in an intricate balance. Potent
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
microbicidal mechanisms can be used by infiltrating immune cells, such as neutrophils, to …
Oxidative stress: an essential factor in the pathogenesis of gastrointestinal mucosal diseases
A Bhattacharyya, R Chattopadhyay… - Physiological …, 2014 - journals.physiology.org
Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …
Extracellular/microenvironmental redox state
L Chaiswing, TD Oberley - Antioxidants & redox signaling, 2010 - liebertpub.com
Extracellular redox (reduction–oxidation) state is a factor that serves as an important
regulator of cell–microenvironmental interactions and is determined by several known …
regulator of cell–microenvironmental interactions and is determined by several known …
The thioredoxin system of mammalian cells and its modulators
AA Hasan, E Kalinina, V Tatarskiy, A Shtil - Biomedicines, 2022 - mdpi.com
Oxidative stress involves the increased production and accumulation of free radicals,
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS) …
Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease
AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …
Principles in redox signaling: from chemistry to functional significance
A Bindoli, MP Rigobello - Antioxidants & redox signaling, 2013 - liebertpub.com
Reactive oxygen and nitrogen species are currently considered not only harmful byproducts
of aerobic respiration but also critical mediators of redox signaling. The molecules and the …
of aerobic respiration but also critical mediators of redox signaling. The molecules and the …