Metabolism of nicotine to inactive cotinine by hepatic enzyme CYP2A6 is the principal
pathway by which active nicotine is removed from circulation. We therefore hypothesized …

Studies were undertaken to examine whether methoxsalen (9-methoxyfuro [3, 2-g][1]
benzopyran-7-one), a specific and relatively selective inhibitor of human CYP2A6, inhibited …

Introduction: The use of novel oral nicotine delivery devices and compositions for human
consumption and for animal research studies has been increasing in the last several years …

Rationale Cyp2a5, the mouse homologue of human CYP2A6, encodes for the enzyme
responsible for the primary metabolism of nicotine. Variation in human CYP2A6 activity can …

Background Nicotine establishes and maintains tobacco dependence. Individuals with
genetically deficient CYP2A6 nicotine metabolism are at lower risk to become smokers and …

Nicotine is metabolized to the inactive metabolite cotinine by cytochrome P450 2A6. NNK, or
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is a potent procarcinogen shown to be …

The present study focused on the evaluation of nicotine abstinence syndrome in mice and
on the influence of calcium channel blockers on the expression of the somatic signs of …

CYP2A6 is the principle enzyme metabolizing nicotine to its inactive metabolite cotinine. In
this study, the selective probe reactions for each major cytochrome P450 (P450) were used …

Our current study aims to evaluate the mechanisms of tranylcypromine (TCP)-mediated
enhancement of nicotine self-administration. We replicated our previous findings which …

This study aimed at elucidating the in vivo metabolism of nicotine both with and without
inhibitors of nicotine metabolism. Second, the role of mouse CYP2A5 in nicotine oxidation in …