This study aimed at elucidating the in vivo metabolism of nicotine both with and without
inhibitors of nicotine metabolism. Second, the role of mouse CYP2A5 in nicotine oxidation in …

CYP2A5, a mouse cytochrome P450 monooxygenase that shows high similarities to human
CYP2A6 and CYP2A13 in protein sequence and substrate specificity, is expressed in …

Nicotine has been definitively shown to be critically involved in the neural bases of tobacco
addiction. However, nicotine releases a wide variety of neurotransmitters. Nicotine-induced …

The nicotine withdrawal syndrome was validated and characterized in the mouse using both
somatic and affective measures after infusion with nicotine daily via subcutaneous …

Mecamylamine, a noncompetitive nicotinic cholinergic antagonist, inhibits nicotine self-
administration in animals and may attenuate tobacco smoking in humans trying to quit. Our …

Rationale Despite increased education regarding its dangers, cigarette smoking remains a
significant public health concern due to serious associated health consequences such as …

Rationale The ability of nicotine to induce dependence (result in a withdrawal syndrome) is
typically thought to require long-term, daily smoking. Emerging evidence suggests that …

During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by
cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been …

Rationale Recent preclinical data has implicated the α7 nicotinic acetylcholine receptor
(nAChR) as a target in modulating nicotine reward. However, the role of the channel …

Nicotine (NIC), the main psychostimulant compound of smoked tobacco, exerts its effects
through activation of central nicotinic acetylcholine receptors (nAChR), which become up …