Circadian rhythms are altered in several diseases associated with aging, one of which is
Alzheimer's disease (AD). One example of a circadian rhythm is the rest-activity cycle, which …

The effects of age on the circadian clock system have been extensively studied, mainly in
two rodent species, the laboratory rat and the golden hamster. However, less information is …

Alzheimer disease (AD) is a growing health problem globally, which causes a progressive
decline in learning and memory and multiple disturbances of circadian rhythms. Six …

Circadian symptoms have long been observed in Alzheimer's disease (AD) and often
appear before cognitive symptoms, but the mechanisms underlying circadian alterations in …

Using a rodent model for neuropathology induced by human amyloid precursor protein, the
present study tested the hypothesis that 24 h rest/activity rhythms deteriorate with age. A …

Circadian disturbances, including a fragmented sleep–wake pattern and sundowning, are
commonly reported early in the progression of Alzheimer's disease (AD). These changes are …

Age-related effects on circadian rhythms include reductions of rhythm amplitude, alterations
in re-entrainment, and increased fragmentation. Currently, the pattern of these changes …

Previous reports of age effects on circadian period in rodents show a slight shortening of
period with age, with the exception of house mice (Mus domesticus) where a number of …

Critical biological processes are under control of the circadian clock. Disruption of this clock,
eg during aging, results in increased risk for development of chronic disease. Exercise is a …

The Tg2576 mouse model of Alzheimer's disease (AD) exhibits age-dependent amyloid β
(Aβ) deposition in the brain. We studied electroencephalographically defined sleep and the …