Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

A Kotsakis Ruehlmann, S Sammallahti… - Molecular …, 2023 - nature.com
Prenatal maternal stressful life events are associated with adverse neurodevelopmental
outcomes in offspring. Biological mechanisms underlying these associations are largely …

Epigenome-wide association studies of prenatal maternal mental health and infant epigenetic profiles: a systematic review

E Drzymalla, KS Crider, A Wang, G Marta… - Translational …, 2023 - nature.com
Prenatal stress and poor maternal mental health are associated with adverse offspring
outcomes; however, the biological mechanisms are unknown. Epigenetic modification has …

An epigenome-wide association meta-analysis of prenatal maternal stress in neonates: A model approach for replication

J Rijlaarsdam, I Pappa, E Walton… - Epigenetics, 2016 - Taylor & Francis
Prenatal maternal stress exposure has been associated with neonatal differential DNA
methylation. However, the available evidence in humans is largely based on candidate …

DNA methylation as a mediator in the association between prenatal maternal stress and child mental health outcomes: Current state of knowledge

N Azar, L Booij - Journal of affective disorders, 2022 - Elsevier
Background Prenatal maternal stress is increasingly recognized as a risk factor for offspring
mental health challenges. DNA methylation may be a mechanism, but few studies directly …

Newborn genome-wide DNA methylation in association with pregnancy anxiety reveals a potential role for GABBR1

EB Vangeel, E Pishva, T Hompes, D van den Hove… - Clinical …, 2017 - Springer
Background There is increasing evidence for the role of prenatal stress in shaping offspring
DNA methylation and disease susceptibility. In the current study, we aimed to identify genes …

Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study

F Serpeloni, K Radtke, SG de Assis, F Henning… - Translational …, 2017 - nature.com
Stress during pregnancy may impact subsequent generations, which is demonstrated by an
increased susceptibility to childhood and adulthood health problems in the children and …

Maternal anxiety during pregnancy and newborn epigenome-wide DNA methylation

S Sammallahti, AP Cortes Hidalgo, S Tuominen… - Molecular …, 2021 - nature.com
Maternal anxiety during pregnancy is associated with adverse foetal, neonatal, and child
outcomes, but biological mechanisms remain unclear. Altered foetal DNA methylation …

Epigenetics of prenatal stress in humans: the current research landscape

L Dieckmann, D Czamara - Clinical Epigenetics, 2024 - Springer
Fetal exposure to prenatal stress can have significant consequences on short-and long-term
health. Epigenetic mechanisms, especially DNA methylation (DNAm), are a possible …

Does maternal mental well-being in pregnancy impact the early human epigenome?

J Ryan, T Mansell, P Fransquet, R Saffery - Epigenomics, 2017 - Taylor & Francis
There is considerable interest in the potential nongenetic transmission of a suite of mental
health conditions across generations, with epigenetics emerging as a candidate mediator of …

Stress during pregnancy and epigenetic modifications to offspring DNA: a systematic review of associations and implications for preterm birth

AL Nowak, CM Anderson, AR Mackos… - The Journal of …, 2020 - journals.lww.com
Offspring born preterm (ie, before 37 weeks of gestation) are more likely to die or experience
long-standing illness than full-term offspring. Maternal genetic variants (ie, heritable, stable …