It is well known that many patients complain about sensory abnormalities involving chronic
pain. Mechanical allodynia is defined as pain caused by stimuli that do not normally evoke …

Dynamic mechanical allodynia is a widespread and intractable symptom of neuropathic pain
for which there is a lack of effective therapy. We recently provided a novel perspective on the …

Neuropathic pain is poorly managed by conventional analgesic therapy, such as non-
steroidal anti-inflammatory drugs and opiates.[1, 4, 7] The development of animal models of …

Although considerable evidence exists that spinal neurokinin1 receptors are involved in
central sensitization of nociception, recent evidence from knockout studies indicates that …

Sensory information from nociceptors and touch receptors, such as Aβ-fiber
mechanoreceptors and C-fiber low-threshold mechanoreceptors (C-LTMRs), is normally …

Kinin B1 and B2 receptor (R) gene expression (mRNA) is increased in the sensory system
after peripheral nerve injury. This study measured the densities of B1R and B2R binding …

The Tac4 gene-derived hemokinin-1 (HK-1) is present in pain-related regions and activates
the tachykinin NK1 receptor, but with binding site and signaling pathways different from …

Neuropathic pain syndromes, ie, pain after a lesion or disease of the peripheral or central
nervous system, are clinically characterized by spontaneous pain (ongoing, paroxysms) and …

Neuropathic pain refers to a specific pain syndrome characterized by pain and sensory
abnormalities in body parts that have lost their normal peripheral innervation or sensory …

Although many studies have demonstrated a role for substance P in pain, there have been
conflicting reports implicating the involvement of substance P in neuropathic pain models. In …