Bradykinin (BK) is well known as a potent mediator of pain and hyperalgesia. Using a highly
sensitive nociception test, we found that intraplantar (i. pl.) injection of BK produced …

Discovery of the occurrence of neurokinin-1 (NK-1) receptor internalization in response to
agonist activation has provided researchers with a new tool for studying tachykinin actions …

Neuropathic pain, pain arising as a direct consequence of a lesion or disease affecting the
somatosensory system, is relatively common, occurring in about 1% of the population …

Neuropathic pain is typically accompanied by a constellation of signs and symptoms that
gives to this condition a very distinct presentation. Allodynia--pain sensation induced by non …

Substance P is known to exert various pro-inflammatory effects that are mediated by
neurokinin-1 (NK-1) receptor in peripheral tissues. This study examined the effect of the NK …

The involvement of tachykinin neuropeptides, such as substance P and the neurokinins, in
pain transmission is supported by a wealth of evidence. At present. the therapeutic potential …

Opioid receptors and neurokinin 1 receptor (NK1R) are found highly expressed in the
central nervous system. The co-localization of these two kinds of receptors suggests that …

The mammalian tachykinins (substance P, neurokinin A, and neurokinin B) are widely
distributed throughout the central and peripheral nervous systems, where they act as …

Mechanical allodynia is a debilitating pain from innocuous mechanical stimuli such as touch.
To unravel its mechanism, one approach has been to focus on the fact that different afferent …

Objectives: Noxious stimuli activate small to medium-sized dorsal root ganglion (DRG)
neurons. Intense noxious stimuli result in the release of substance P (SP) from the central …