Allodynia and hyperalgesia are prominent symptoms in patients with neuropathic pain. Both
are seen in various peripheral neuropathies and central pain disorders, and affect 15–50 …

Blockade of local spinal cord inhibition mimics the behavioral hypersensitivity that manifests
in chronic pain states. This suggests that there is a pathway capable of mediating …

Pain may begin in the periphery with activation of nociceptor transducers. The present article
reviews the pharmacology of drug action at the level of the primary afferent by discussing the …

Since the failure of specific substance P antagonists to induce analgesia, the role of
tachykinins in the development of neuropathic pain states has been discounted. This …

Peripheral nerve injury is associated with hyperesthesia and increased neurokinin-1
receptor (NK-1) expression in the dorsal horn of the spinal cord. To test the hypothesis that …

This book is the result of a five-day meeting in Scottsdale, Arizona, in April 2005, with the
purpose of developing new ways to treat neuropathic pain (NP). It is divided into four parts …

Increased pain Sensitivity was traditionally attributed to sensitization of primary nociceptive
afferents. The discovery that low-threshold mechanoreceptor input can be painful under …

N laminae, no deeper than Rexed II (substantia gelatinosa). Larger afferent Aß fibres
terminate in Rexed III and deeper, carrying touch and other innocuous sensations. Following …

Objective: intra-articular co-injection of kaolin with carrageenan (CGN) in rodents is widely
used as an experimental model of arthritis. However, the ability of kaolin to cause arthritis …