The goal of any early central nervous system (CNS) drug development program is always to
test the mechanism and not the molecule in order to support additional research investments …

As drug discovery and development in Neuroscience push beyond symptom management
to disease modification, neuroimaging becomes a key area of translational research that …

Positron emission tomography (PET) is an extensively used nuclear functional imaging
technique, especially for central nervous system (CNS) and oncological disorders. Currently …

Molecular imaging methods such as positron emission tomography (PET) are increasingly
involved in the development of new drugs. Using radioactive tracers as imaging probes, PET …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Neuroscientists of today dispose of a powerful armament for functional, physiological, and
molecular imaging that has never made more impressive advances than before, helping to …

Rationale This review attempts to summarize the current status in relation to the use of
positron emission tomography (PET) imaging in the assessment of synaptic concentrations …

The physiological functioning of the brain is not well-known in current day medicine and the
pathologies of many neuropsychiatric disorders are still not yet fully understood. With our …

In this review, the value of functional imaging [positron emission tomography (PET)/single-
photon emission computed tomography (SPECT)] in drug development is considered …

The discovery and development of central nervous system (CNS) drugs is an extremely
challenging process requiring large resources, timelines, and associated costs. The high …