Osteoarthritis (OA) is a complicated degenerative disease that affects whole joint tissue.
Currently, apart from surgical approaches to treat late stage OA, effective treatments to …

PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA).
However, its potential modulatory role in early OA progression has not been investigated …

Osteoarthritis is characterized by degenerative alterations of articular cartilage including
both the degradation of extracellular matrix and the death of chondrocytes. The PI3K/Akt …

Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

Osteoarthritis (OA) is a multifactorial chronic disease primarily characterized by the
degeneration of articular cartilage. Currently, there is a lack of effective treatments for OA …

Osteoarthritis (OA) is a painful and debilitating condition of synovial joints without any
disease-modifying therapies [AM Valdes, TD Spector, Nat. Rev. Rheumatol. 7, 23–32 …

Abstract Interleukin 18 (IL-18) promotes inflammation and apoptosis in chondrocytes,
thereby contributing to the development and progression of osteoarthritis (OA). Here, we …

Chronic, low-grade inflammation in osteoarthritis (OA) contributes to symptoms and disease
progression. Effective disease-modifying OA therapies are lacking, but better understanding …

Osteoarthritis (OA) and posttraumatic OA (PTOA) are caused by an imbalance in catabolic
and anabolic processes in articular cartilage and proinflammatory changes throughout the …

Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators,
such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum …