Inteins are naturally occurring proteins that are involved in the precise cleavage and
formation of peptide bonds in a process known as protein splicing. Genetic engineering has …

Protein trans-splicing mediated by a split intein reconstitutes a protein backbone from two
parts. This virtually traceless autoprocessive reaction provides the basis for numerous …

The judicious application of intein technologies to biological problems has resulted in
powerful tools for biomedical research. Inteins are intervening sequences that excise …

Inteins catalyze self‐excision from host precursor proteins while concomitantly ligating the
flanking substrates (exteins) with a peptide bond. Noncatalytic extein residues near the …

Inteins catalyze a post-translational modification known as protein splicing, where the intein
removes itself from a precursor protein and concomitantly ligates the flanking protein …

Inteins catalyze a protein splicing reaction to excise the intein from a precursor protein and
join the flanking sequences (exteins) with a peptide bond. In a split intein, the intein …

Protein splicing is a process in which an intervening sequence, the intein, catalyzes its own
excision out of a larger polypeptide precursor by joining the flanking sequences, the exteins …

Coulombic forces play an important role in facilitating protein–protein interactions. It has
been demonstrated that a strong electrostatic potential between two interacting proteins …

Protein splicing catalyzed by inteins has enabled various biotechnological applications such
as protein ligation. Successful applications of inteins are often limited by splicing efficiency …

Inteins are protein segments embedded in frame within a precursor sequence that catalyze
a self-excision reaction and ligate the flanking sequences with a standard peptide bond …