Background SPG11-linked hereditary spastic paraplegia is characterized by multisystem
neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive …

Purpose To investigate whether specific patterns of brain gray matter (GM) regional volumes
and white matter (WM) microstructural abnormalities and spinal cord atrophy occur in …

Background: Hereditary spastic paraplegia (HSP) is a clinically and genetically
heterogeneous neurodegenerative disorder characterized by progressive spastic …

SPG11 mutations are the major cause of autosomal recessive Hereditary Spastic
Paraplegia. The disease has a wide phenotypic variability indicating many regions of the …

Background Spinal cord has been considered the main target of damage in hereditary
spastic paraplegias (HSPs), but mounting evidence indicates that the brain is also affected …

Background Mutations in SPG11 are the most frequent known cause of autosomal recessive
hereditary spastic paraplegia. Corpus callosum thinning is a hallmark of the condition but …

Objective: To investigate the progression of cognitive impairment and its behavioral aspects
in patients with SPG4-linked autosomal dominant hereditary spastic paraplegia (SPG4 …

The aim of this study was to identify potential diagnostic markers of Hereditary Spastic
Paraplegia (HSP). We investigated the white matter features of spastic gait (SPG) 11-and …

Background To analyze the clinical phenotype of hereditary spastic paraplegia (HSP)
caused by SPG11 mutations (SPG11-HSP). Methods Among the 17 patients with sporadic …

Hereditary spastic paraplegias (HSP/SPGs) constitute a clinically and genetically
heterogeneous group of neurodegenerative disorders. Inheritance of the disease has been …