Hereditary spastic paraplegia (HSP) refers to a group of neurodegenerative disorders
affecting motor neurons in the central nervous system. HSP type 11 is the most frequent …

Background: Little is known about the cognitive profile of Hereditary Spastic Paraplegias
(HSP), where most scientific attention has been given to motor features related to …

Background Reduction of retinal nerve fibre layer (RNFL) thickness was shown as part of the
neurodegenerative process in a range of different neurodegenerative pathologies including …

Hereditary spastic paraplegia type 11 (SPG11) is the most common subtype of autosomal
recessive hereditary spastic paraplegia (HSP), to date, there are more than 181 different …

Background: Cognitive impairment and dementia has been reported in autosomal dominant
hereditary spastic paraparesis (HSP) linked to the SPG4 locus. There has only been one …

Seven families with six different SPG3A mutations were identified among 106 with
autosomal dominant hereditary spastic paraplegia (HSP). Two mutations were novel …

Background and objectives Hereditary spastic paraplegias (HSPs) are heterogenous
genetic disorders characterized by progressive pyramidal tract involvement. SPG76 is a …

Background Hereditary spastic paraplegias (HSP) is a heterogeneous group of rare
neurodegenerative disorders affecting the corticospinal tracts. To date, more than 78 HSP …

Hereditary spastic paraplegias (HSPs) are genetically determined neurodegenerative
disorders characterized by progressive weakness and spasticity of lower limbs, and are …

Besides medical history, clinical evaluation and laboratory analysis, magnetic resonance
imaging (MRI) represents an incomparable tool for a complete MS diagnostic work-up [2]; …