Importance Hereditary spastic paraplegias (HSPs) are a group of diseases caused by
corticospinal tract degeneration. Mutations in 3 genes (SPG4, SPG3, and SPG31) are said to …

The hereditary spastic paraplegias are a heterogeneous group of degenerative disorders
that are clinically classified as either pure with predominant lower limb spasticity, or complex …

Spastic paraplegia type 7 is an autosomal recessive neurodegenerative disorder mainly
characterized by progressive bilateral lower limb spasticity and referred to as a form of …

Hereditary spastic paraplegia (HSP) is a neurodegenerative disease characterized by
progressive weakness and spasticity of the lower limbs, in complicated forms, with additional …

Mutations in the SPG4 gene are the most common causes of hereditary spastic paraplegia
(HSP) accounting for up to 40% of autosomal dominant (AD) forms and 12–18% of sporadic …

Background: Mutations in the SPG7 gene, which encodes paraplegin, are responsible for an
autosomal recessive hereditary spastic paraplegia (HSP). Objective: To screen the SPG7 …

Background: Pathogenic variants in SPG11 cause the most common autosomal recessive
complicated hereditary spastic paraplegia. Besides the prototypical combination of spastic …

Complex hereditary spastic paraplegia (HSP) is a clinically heterogeneous group of
disorders usually inherited in an autosomal recessive manner. In the past, complex …

Objectives. To describe cognitive assessment including social cognition in SPG4 patients.
Methods. We reported a series of nine patients with SPG4 mutation with an extensive …

BACKGROUND AND PURPOSE: In spastic paraplegia type 5, spinal cord atrophy and white
matter signal abnormalities in the brain are the main MR imaging alterations. However, the …