Background and purpose SPG 7 is one of the most common forms of autosomal recessive
hereditary spastic paraplegia. The phenotype has been shown to be heterogeneous …

The hereditary spastic paraplegias (HSPs) are a genetically heterogeneous group of
disorders characterised by progressive corticospinal tract degeneration and the …

Hereditary spastic paraplegias (HSPs) are a clinically and genetically heterogeneous group
of neurodegenerative disorders characterized by progressive spasticity and weakness of the …

Hereditary spastic paraplegias (HSPs) are clinically and genetically highly heterogeneous.
The key symptom of spastic paraparesis of lower limbs can be complicated by a variety of …

Aims The hereditary spastic paraplegias (HSPs) are a heterogeneous group of inherited
neurodegenerative disorders. Although, several genotype–phenotype studies have carried …

OBJECTIVE: To assess in SPG5 hereditary spastic paraparesis (HSP) the involvement of the
central (CNS) and the peripheral (PNS) nervous system by a multimodal …

Background Spastic paraplegia type 8 (SPG8) is an autosomal-dominant form of hereditary
spastic paraplegia (AD-HSP) caused by a mutation in the KIAA0196 gene. SPG8 accounts …

Background: Hereditary spastic paraplegias constitute a heterogeneous group of inherited
neurodegenerative disorders. To date, there has been no systematic mutation and clinical …

Objective Hereditary spastic paraplegias (HSP) is a clinically and genetically heterogeneous
group of neurodegenerative disorders. We describe the genetic and clinical features of a …

Background A pair of monozygotic 22-year-old twins with complicated hereditary spastic
paraplegia caused by a novel SPG11 mutation is described. Methods Genetic testing and …