Development and validation of a score to assess transmural healing and response in patients with Crohn's disease

A Buisson, J Junda, E Lecoq, G Bouguen… - Clinical …, 2024 - Elsevier
ABSTRACT Background and Aims As transmural healing (TH) could be the best therapeutic
target in Crohn's disease (CD), we aimed to build and validate a score to assess TH and …

P120 Development and validation of a dedicated score to assess transmural response and transmural healing in patients with Crohn's disease: final results of the …

A Buisson, J Junda, J Vignette, E Lecoq… - Journal of Crohn's …, 2023 - academic.oup.com
Background Transmural healing (TH) is associated with better outcomes that endoscopic
remission in Crohn's disease (CD) but is not yet considered as therapeutic target owing to …

Exploring the concept of deep remission in Crohn's disease: correlation between transmural healing and biomarkers

F Castiglione, N Imperatore, A Testa… - Therapeutic …, 2022 - journals.sagepub.com
Background: While mucosal healing (MH) and transmural healing (TH) predict relevant
clinical outcomes in Crohn's disease (CD), little is known about the real significance and …

Transmural healing as a therapeutic goal in Crohn's disease: a systematic review

S Geyl, L Guillo, V Laurent, F d'Amico… - The lancet …, 2021 - thelancet.com
Transmural healing is associated with substantial improvements in disease-related
outcomes for patients with Crohn's disease, but there is no single validated definition of …

Comparison of transmural healing and mucosal healing as predictors of positive long-term outcomes in Crohn's disease

L Ma, W Li, N Zhuang, H Yang, W Liu… - Therapeutic …, 2021 - journals.sagepub.com
Background: Transmural healing (TH) is being increasingly recognized for reflecting deep
remission in Crohn's disease (CD). The long-term clinical significance of achieving TH is still …

Cross-sectional evaluation of transmural healing in patients with Crohn's disease on maintenance treatment with anti-TNF alpha agents

F Castiglione, P Mainenti, A Testa, N Imperatore… - Digestive and Liver …, 2017 - Elsevier
Background Transmural healing (TH) of Crohn's disease (CD) is a still unexplored and
interesting outcome correlated to concept of deep remission. Aim To assess the rate of TH in …

Targeting the gut layers in Crohn's disease: mucosal or transmural healing?

E Zacharopoulou, V Craviotto, G Fiorino… - Expert Review of …, 2020 - Taylor & Francis
Introduction Although the landmark of Crohn's Disease (CD) is the transmural inflammation,
mucosal healing (MH), which is assessed by colonoscopy, is currently the gold standard of …

[HTML][HTML] Treat-to-target in Crohn's disease: will transmural healing become a therapeutic endpoint?

ED Serban - World Journal of Clinical Cases, 2018 - ncbi.nlm.nih.gov
Crohn's disease (CD) represents a chronic transmural inflammatory condition of the
gastrointestinal tract, which usually leads to structural damage and significant disability …

Transmural healing is associated with improved long-term outcomes of patients with Crohn's disease

SR Fernandes, RV Rodrigues… - Inflammatory bowel …, 2017 - academic.oup.com
Background Mucosal healing (MH) is currently accepted as one of the best treatment targets
in Crohn's disease. However, even in patients with sustained MH, residual bowel wall …

Transmural healing and MRI remission: new promising therapeutic targets in Crohn's disease

A Buisson, C Hordonneau… - Inflammatory bowel …, 2017 - academic.oup.com
We read with great interest the article by Fernandes et al published in a recent issue of
Inflammatory Bowel Diseases. Although magnetic resonance imaging (MRI) is a reliable tool …