Topical nitrogen mustard exposure causes systemic toxic effects in mice

DG Goswami, D Kumar, N Tewari-Singh… - Experimental and …, 2015 - Elsevier
Vesicating agents sulfur mustard (SM) and nitrogen mustard (NM) are reported to be easily
absorbed by skin upon exposure causing severe cutaneous injury and blistering. Our …

Toxicology and pharmacology of the chemical warfare agent sulfur mustard.

JC Dacre, M Goldman - Pharmacological reviews, 1996 - ASPET
There have been reports of chemical attacks in which sulfur mustard might have been used
(a) on Iranian soldiers and civilians during the Gulf War in 1984 and 1985 and (b) in an Iraqi …

Cognitive and emotional impairments after cutaneous intoxication by CEES (a sulfur mustard analog) in mice

F Gros-Désormeaux, D Béracochéa, F Dorandeu… - Toxicology Letters, 2018 - Elsevier
Cognitive and emotional disorders have been reported in veterans intoxicated with sulfur
mustard (SM) a chemical weapon belonging to the category of vesicating agents. However …

Assessment of the biochemical effects of percutaneous exposure of sulphur mustard in an in vitro human skin system

CD Lindsay, P Rice - Human & experimental toxicology, 1996 - journals.sagepub.com
1 Sulphur mustard (HD) is a potent chemical warfare agent which causes incapacitating
blisters on human skin. There is no specific pretreatment nor therapy against this agent and …

Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin

AK Jain, N Tewari-Singh, S Inturi, D Kumar… - Toxicology and applied …, 2015 - Elsevier
Currently, there is no effective antidote to prevent skin injuries by sulfur mustard (SM) and
nitrogen mustard (NM), which are vesicating agents with potential relevance to chemical …

Pathology of nerve agents: perspectives on medical management

CG McLeod Jr - Fundamental and Applied Toxicology, 1985 - Elsevier
Recent investigations at several institutes have demonstrated extensive acute brain
pathology in experimental animals exposed to single subcutaneous doses of the chemical …

Localization of substance P gene expression for evaluating protective countermeasures against sulfur mustard

SL Casbohm, JV Rogers, MK Stonerock, JL Martin… - Toxicology, 2004 - Elsevier
Sulfur mustard [bis (2-chloroethyl) sulfide; SM] is a chemical warfare agent that produces
edema and blister formation with a severe inflammatory reaction. The mouse ear vesicant …

N‐acetylcysteine and endothelial cell injury by sulfur mustard

KB Atkins, IJ Lodhi, LL Hurley… - Journal of Applied …, 2000 - Wiley Online Library
Understanding the underlying mechanisms of cell injury and death induced by the chemical
warfare vesicant sulfur mustard (HD) will be extremely helpful in the development of effective …

The Role of NAD+ Depletion in the Mechanism of Sulfur Mustard–Induced Metabolic Injury

ME Martens, WJ Smith - Cutaneous and ocular toxicology, 2008 - Taylor & Francis
Results of our previous studies on the chemical warfare agent sulfur mustard (2, 2′-
dichlorodiethyl sulfide) suggested that mustard-induced inhibition of glycolysis is not solely a …

Signal transduction events in lung injury induced by 2‐chloroethyl ethyl sulfide, a mustard analog

D Chatterjee, S Mukherjee, MG Smith… - Journal of biochemical …, 2003 - Wiley Online Library
Sulfur mustard has been used as a vesicant chemical warfare agent. To understand the
mechanism by which mustard gas exposure causes respiratory damage, we have used 2 …