Background In eukaryotes, alternative splicing often generates multiple splice variants from
a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address …

Background Full-length isoform quantification from RNA-Seq is a key goal in transcriptomics
analyses and has been an area of active development since the beginning. The …

Recent study revealed that most human genes have alternative splicing and can produce
multiple isoforms of transcripts. Differences in the relative abundance of the isoforms of a …

Motivation: Alternative splicing (AS) is a pre-mRNA maturation process leading to the
expression of multiple mRNA variants from the same primary transcript. More than 90% of …

Motivation Alternative splicing removes intronic sequences from pre-mRNAs in alternative
ways to produce different forms (isoforms) of mature mRNA. The composition of expressed …

Background Massively parallel whole transcriptome sequencing, commonly referred as RNA-
Seq, is quickly becoming the technology of choice for gene expression profiling. However …

Motivation: The deconvolution of isoform expression from RNA-seq remains challenging
because of non-uniform read sampling and subtle differences among isoforms. Results: We …

Motivation: Isoform quantification is an important goal of RNA-seq experiments, yet it
remains problematic for genes with low expression or several isoforms. These difficulties …

Background The development of techniques for sequencing the messenger RNA (RNA-Seq)
enables it to study the biological mechanisms such as alternative splicing and gene …

Background While the reconstruction of transcripts from a sample of RNA-Seq data is a
computationally expensive and complicated task, the detection of splicing events from RNA …