In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Osteosarcoma is a relatively uncommon malignancy with about 1000 new cases diagnosed
each year in the United States. It is, however, among the most common nonhematologic …

Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in
children and adolescents relative to other age groups. The etiology of this often aggressive …

Despite the knowledge of many of the genetic alterations present in osteosarcoma, its
complexity precludes placing its biology into a simple conceptual framework. In contrast to …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Osteosarcoma is the most common primary tumor of bone, yet its absolute incidence among
malignant tumors is low. Within its strict histologic definition, osteosarcoma comprises a …

Osteosarcoma is the most common primary malignancy of bone in children and young
adults. This tumor has a very heterogeneous genetic profile and lacks any consistent …

Our aim was to identify chromosomal regions that are likely to harbor previously unknown
genes with an important role in the genesis of osteosarcoma. Comparative genomic …

This book is an up-to-date compilation of chromosome findings on bone and soft tissue
tumors. The book indicates the specificity of these changes and their relation to distinct …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …