The Warburg effect: insights from the past decade

M Upadhyay, J Samal, M Kandpal, OV Singh… - Pharmacology & …, 2013 - Elsevier
Several decades ago, Otto Warburg discovered that cancer cells produce energy
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …

The Warburg effect and its cancer therapeutic implications

Z Chen, W Lu, C Garcia-Prieto, P Huang - Journal of bioenergetics and …, 2007 - Springer
Increased aerobic glycolysis in cancer, a phenomenon known as the Warburg effect, has
been observed in various tumor cells and represents a major biochemical alteration …

The Warburg effect: how does it benefit cancer cells?

MV Liberti, JW Locasale - Trends in biochemical sciences, 2016 - cell.com
Cancer cells rewire their metabolism to promote growth, survival, proliferation, and long-term
maintenance. The common feature of this altered metabolism is the increased glucose …

The Warburg effect: molecular aspects and therapeutic possibilities

H Ngo, SM Tortorella, K Ververis… - Molecular biology …, 2015 - Springer
It has been about nine decades since the proposal of Otto Warburg on the metabolism of
cancer cells. Unlike normal cells which undergo glycolysis and oxidative phosphorylation in …

The Warburg effect 97 years after its discovery

RM Pascale, DF Calvisi, MM Simile, CF Feo, F Feo - Cancers, 2020 - mdpi.com
Simple Summary The deregulation of the oxidative metabolism in cancer cells,
characterized by an increased ratio between glycolysis and oxygen consumption (Warburgv …

Otto Warburg's contributions to current concepts of cancer metabolism

WH Koppenol, PL Bounds, CV Dang - Nature Reviews Cancer, 2011 - nature.com
Otto Warburg pioneered quantitative investigations of cancer cell metabolism, as well as
photosynthesis and respiration. Warburg and co-workers showed in the 1920s that, under …

Warburg effect (s)—a biographical sketch of Otto Warburg and his impacts on tumor metabolism

AM Otto - Cancer & metabolism, 2016 - Springer
Virtually everyone working in cancer research is familiar with the “Warburg effect”, ie,
anaerobic glycolysis in the presence of oxygen in tumor cells. However, few people …

Cancer cell metabolism: Warburg and beyond

PP Hsu, DM Sabatini - Cell, 2008 - cell.com
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark
of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg …

[HTML][HTML] Emerging metabolic targets in cancer therapy

Y Zhao, H Liu, AI Riker, O Fodstad… - … in bioscience: a …, 2011 - ncbi.nlm.nih.gov
Cancer cells are different from normal cells in their metabolic properties. Normal cells mostly
rely on mitochondrial oxidative phosphorylation to produce energy. In contrast, cancer cells …

Warburg effect and its role in tumourigenesis

MT Lebelo, AM Joubert, MH Visagie - Archives of pharmacal research, 2019 - Springer
Glucose is a crucial molecule in energy production and produces different end products in
non-tumourigenic-and tumourigenic tissue metabolism. Tumourigenic cells oxidise glucose …